Dissociation of a hydrophobic surface from phagocytosis of encapsulated and non-encapsulated cryptococcus neoformans
نویسندگان
چکیده
منابع مشابه
Opsonization of encapsulated Cryptococcus neoformans by specific anticapsular antibody.
Antisera prepared in rabbits against either whole encapsulated cells of Cryptococcus neoformans or purified cryptococcal polysaccharide were opsonic for the encapsulated yeast. The opsonic activity was removed by absorption with whole cryptococci and was inhibited by free polysaccharide. As little as 0.13 microgram of cryptococcal polysaccharide produced a 50% inhibition of opsonization. Variou...
متن کاملCryptococcus neoformans. 3. Inhibition of phagocytosis.
Isolated nonhydrolyzed cryptococcal polysaccharide is a rather specific potent inhibitor of the phagocytosis of Cryptococcus neoformans by human leukocytes in vitro. When an encapsulated strain of C. neoformans was cultured in the nonencapsulated state, the rate of phagocytosis was three times greater than when the encapsulated form was used. Our theory that capsular material plays a role in th...
متن کاملIn vivo complement activation and binding of C3 to encapsulated Cryptococcus neoformans.
Tissues from mice infected with Cryptococcus neoformans were examined by immunofluorescence to determine the extent of deposition of complement component C3 on encapsulated cryptococci. The relative percentages of cryptococci in each tissue having readily visible C3 were greatest for liver and lung tissues, with the kidney tissue having the next highest percentage and the spleen having the lowe...
متن کاملModulation of C5aR expression on human neutrophils by encapsulated and acapsular Cryptococcus neoformans.
Cryptococcus neoformans and cryptococcal surface polysaccharides influenced C5aR expression on human polymorphonuclear neutrophils (PMN). Encapsulated and acapsular strains produced dramatically different effects. Treatment of PMN with acapsular cryptococci up-regulated C5aR expression; whereas treatment with encapsulated cells suppressed C5aR expression. Glucuronoxylomannan (GXM), the principa...
متن کاملPhagocytosis, with particular reference to encapsulated bacteria.
The phagocytic cells of the mammalian host provide a remarkable defense against a wide variety of bacteria, fungi, and protozoa. Whether they play a protective role in infections caused by viruses and rickettsiae is at present a matter of conjecture. The discovery of "pinocytosis" (Gey, 1954), however, and recent observations relating to bacterial endotoxins (Berthrong and Cluff, 1953; Braude e...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 1983
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.39.3.1214-1219.1983